Complex thermorheology of living cells

Sebastian Schmidt et al. from the Universität Leipzig published a study comparing the thermorheological behaviour of eight different cell lines. They undermined the previously published statement that temperature changes largely affect deformation measurements of cells. The time-temperature superposition principle does not hold for all measured cell lines due to non-linear temperature dependence of intracellular processes. Three categories of cellular response were identified and could be explained by different structural organization of the cells. Therefore studying thermorheological behaviour can give valuable insights to the load bearing structures in the cell types.
 
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